Today , we will study the most harmful element of 2 viruses , #CoronaVirus and #HIV.
SPIKE PROTEIN IN CORONA VIRUS
Identification and sequencing of the virus responsible for COVID-19 (view SARS-CoV-2 protein sequence) determined that it was a novel CoV that shared 88% sequence identity with two bat-derived SARS-like CoV, suggesting it had originated in bats.
Additionally, it was shown that this CoV, which was termed 2019-nCoV or SARS-CoV-2, shared 79.5% sequence identity with SARS-CoV. The coronaviral genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein.
The S protein is responsible for facilitating entry of the CoV into the target cell.
It is composed of a short intracellular tail, a transmembrane anchor, and a large ectodomain that consists of a receptor binding S1 subunit and a membrane-fusing S2 subunit.
Sequence analysis of the SARS-CoV-2 S protein genome showed that it was only 75% identical with the SARS-CoV S protein.
However, analysis of the receptor binding motif (RBM) in the S protein showed that most of the amino acid residues essential for receptor binding were conserved between SARS-CoV and SARS-CoV-2, suggesting that the 2 CoV strains use the same host receptor for cell entry.
The entry receptor utilized by SARS-CoV is Angiotensin-Converting Enzyme 2 (ACE-2).
Now , we will look into GP41 from HIV .
GP41 OF HIV
Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells.
SIMILIARITY :
Recently you must have heard this news that CORONA VIRUS Patients in India ( Rajasthan ,India ) was cured with HIV Drugs.
city-docs-cure-corona-patient-with-hiv-drugs
People then might have laughed but think twice once you read the above .
A research paper by IITd which was later withdrawn had the below conclusion :
Read the Series Here :
SPIKE PROTEIN IN CORONA VIRUS
Identification and sequencing of the virus responsible for COVID-19 (view SARS-CoV-2 protein sequence) determined that it was a novel CoV that shared 88% sequence identity with two bat-derived SARS-like CoV, suggesting it had originated in bats.
Additionally, it was shown that this CoV, which was termed 2019-nCoV or SARS-CoV-2, shared 79.5% sequence identity with SARS-CoV. The coronaviral genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein.
The S protein is responsible for facilitating entry of the CoV into the target cell.
It is composed of a short intracellular tail, a transmembrane anchor, and a large ectodomain that consists of a receptor binding S1 subunit and a membrane-fusing S2 subunit.
Sequence analysis of the SARS-CoV-2 S protein genome showed that it was only 75% identical with the SARS-CoV S protein.
However, analysis of the receptor binding motif (RBM) in the S protein showed that most of the amino acid residues essential for receptor binding were conserved between SARS-CoV and SARS-CoV-2, suggesting that the 2 CoV strains use the same host receptor for cell entry.
The entry receptor utilized by SARS-CoV is Angiotensin-Converting Enzyme 2 (ACE-2).
Now , we will look into GP41 from HIV .
GP41 OF HIV
Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells.
SIMILIARITY :
Recently you must have heard this news that CORONA VIRUS Patients in India ( Rajasthan ,India ) was cured with HIV Drugs.
city-docs-cure-corona-patient-with-hiv-drugs
People then might have laughed but think twice once you read the above .
A research paper by IITd which was later withdrawn had the below conclusion :
KIND NOTE :
These are very tough times.
The COVID19 Pandemic has created lot of economical hazards all over the world.
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https://www.amazon.in/SECRET-IMMORTAL-CODE-TRILOGY-Trilogy-ebook/dp/B00FBSOPXY
https://www.amazon.com/dp/B00FBSOPXY
Read the Series Here :